Electrification of large commercial HVAC requires an understanding of tradeoffs between energy efficiency and GHG emissions from refrigerants. Current requirements for companies to reduce GHG emissions will move heating technologies to heat pumps and other non-fuel-based technologies. Panelists will discuss design considerations for applications such as campuses, data centers, and general commercial-building comfort applications. Examples of installations from Europe will be shared, and progress in the US will be discussed. And we will take a look at what is being investigated for the future.